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In addition to being directly activated by NAPQI, protein tyrosine phosphatase 1 B (PTP1B), 42 fibroblast growth factor 21 (FGF21), 43 and the M1 muscarinic receptor (M1R) 44 have also been found to modulate the Nrf2 signaling pathway

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Additionally, these values were also comparable to those of 2.5–5.7 h reported in other studies investigating the t 1/2 of caffeine after oral administration [21, 34]